Informatics Publishing Limited

S. C. Shivhare ¹, U. D. Shivhare ², Preeti Srivastav ¹, K. G. Malviya ¹

Affiliations
1 MJRP college of heath Care and Allied Sciences, MJRP university, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN

Abstract

Human vagina represents a dynamic ecosystem dominated by certain species of Lactobacillus. This microorganism restricts the growth of pathogens by using properties of steric exclusion and inhibitory substance production. Serious complications including bacterial vaginosis and vaginal cancer are often determined in women with reduced numbers of lactobacilli. Local application of Lactobacillus is consequently promising to keep the vagina colonized by this strain, which consequently reduces the infections. The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository containing lyophilized culture of Lactobacillus with anti microbial agent clotrimazole. The second objective was to establish a stable clotrimazole suppositiry alone with Lactic acid Bacillus Spores for vaginosis.

Keywords

Vaginosis,Lactic acid bacillus Spores, Clotrimazole, Formulation, Viability, Stability

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S. C. Shivhare ¹, Arjun O. Patidar ¹, K. G. Malviya ², K. Venkatesh ³, Kuldeep Rathod ³

Affiliations
1 BM College of Pharmaceutical Education and Research, Indore (MP), IN
2 Radharaman Institute of Pharmacy, Bhopal (M.P), IN
3 Department of Pharmaceutics, Vels College of Pharmacy Chennai, (T.N), IN

Abstract

Seminal oxidative stress in the male reproductive tract is known to result in peroxidative damage of the sperm plasma membrane and loss of its DNA integrity. Normally, a balance exists between concentrations of reactive oxygen species (ROS) and antioxidant scavenging systems. One of the rational strategies to counteract the oxidative stress is to increase the scavenging capacity of seminal plasma. Numerous studies have evaluated the efficacy of antioxidants in male infertility. In this review, the results of different studies conducted have been analyzed, and the evidence available to date is provided. We outline the role of nutritional and biochemical factors from the nutraceutical of anti oxidant class like lycopenes, selenium, folate, zinc, glutathiones, l-arginine, l-carnitine, coenzyme-Q, Vitamin E,Vitamin C,Vitamin B₁₂ in reproduction and male infertility problem.

Keywords

Nutraceutical, Male Infertility, SOS, ROS, Antioxidants.

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K. G. Malviya ¹, U. D. Shivhare ², Preeti Srivastav ¹, S. C. Shivhare ¹

Affiliations
1 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN

Abstract

The present study was aimed at evaluating the chloroform extracts of whole part of Cyathocline lyrata cass antiinflammatory activity. Anti-inflammatory activity of chloroform extracts of whole part of Cyathocline lyrata cass was evaluated by carrageenan induced hind paw edema and Formalin induced paw edema method. Chloroform extracts of whole part of Cyathocline lyrata cass produced significant Anti-inflammatory activity when evaluated by carrageenan induced hind paw edema and Formalin induced paw edema method respectively. The interpretation of the results was done after subjecting the data obtained from various studies to statistical analysis which included one-way ANOVA followed by post-hoc with Dunnets t-test. The results suggest that the chloroform extracts of whole part of Cyathocline lyrata cass posses anti-inflammatory.

Keywords

Cyathocline lyrata cass, Anti-inflammatory, Carrageenan Induced Hind Paw Edema, Formalin Paw Edema.

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S. C. Shivhare ¹, K. G. Malviya ¹, K. K. Shivhare Malviya ², Neeta K. Rai ³, Vijay Jain ⁴, Arun Kumar ⁵

Affiliations
1 Mahatma Jyoti Rao Phoole College of Health Care and Allied Sciences, MJRP University, Jaipur, Rajasthan, IN
2 Rani Dhullaiya Memorial Ayurvedic College & Hospital, Bhopal, Madhya Pradesh, IN
3 Sagar Institute of Research & Technology, Bhopal, Madhya Pradesh, IN
4 School of Pharmaceutical Sciences, Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bhopal, Madhya Pradesh, IN
5 School of Pharmaceutical Sciences, Vel’s University, Chennai, Tamil Nadu, IN

Abstract

In the present review article many depigmenting or skin lightening as well as nourishing agents are discussed, including their historical background, biochemical characteristics, type of inhibition and activators from various sources. In this article authors have tried to highlights the mechanism and role of Tyrosinase in melanin formation, which pigmenting the skin, with the various important natural agents which altering pigmentation and nourishing the skin like Alpha-Arbutin, Kojic Acid, Licorice Extract, Mulberry, Glycolic Acid, Lactic Acid, Lemon Juice Extract, Vitamin A, Vitamin C, Emblica, Aloe Vera Extract, Grape Seed Extract, Green Tea Extract, Alfalfa Extract, Caviar Extract, Cucumber Fruit extract, Glycerine, Hydrolyzed Soya Protein, Niacin amide, Sugar Cane extract, Safflower seed Oil, Salicylic acid, Squalane, Vitamin E, Watercress extract their sources brief description and the advantages.

Keywords

Whitening, Tyrosinase Inhibitors, Natural Lighting and Nourishing Agents.

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V. S. Parmar ¹, S. C. Shivhare ¹

Affiliations
1 BM College of Pharmaceutical Education and Research, Indore, IN

Abstract

The first objective of this research was to develop a local application pharmaceutical formulation of a vaginal suppository with anti-microbial agent clotrimazole. The second objective was to establish a stable clotrimazole suppository and evaluation of suppository. In the present research a successful attempt to formulate a suppository by fusion method and the various evaluation parameters was done. The microbial test against the causative agents was performed. Finally the stability of the formulation was checked. The inhibitory action of the Clotrimazole suppository was satisfactorily. The methods of its evaluation developed in this research work may be beneficial in preventing bacterial vaginosis. Further investigations have to be carried out in antimicrobial activity in the bacterial viginosis treatment is needed.

Keywords

Vaginosis, Clotrimazole, Formulation, Microbial Test, Stability.

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S. C. Shivhare ¹, K. G. Malviya ², Vijay Jain ³, Guatam Negi ³

Affiliations
1 Sadar bazar B/H Ram Mandir, At post Paratwada, Dist Amravati (M.S) 444805, IN
2 MJRP College of Heath Care and Allied Science, MJRP University, Jaipur, IN
3 BM College of Pharmaceutical Education and Research, Indore(M.P), IN

Abstract

The purpose of this article is to serve as a beginners guide to what the Liposomes as a unique Novel Drug Delivery formulation and to briefly review. liposome's are tools for drug targeting in certain biomedical situations (e.g., cancer, HIV infection, gene therapy etc.) and for reducing the incidence of dose-related drug toxicity. Authors also tried to highlight the various Biomedical applications, Pharmacokinetics of Liposomes, types of liposome and industrial production method of liposomes.

Keywords

Liposomes, Pharmacokinetics, Types, Formulation.

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Arjun Patidar ¹, S. C. Shivhare ², Umesh Ateneriya ¹, Sonu Choudhary ¹

Affiliations
1 BM college of Pharmaceutical Education and Research, Indore, IN
2 MJRPU Health and Allied Science College, MJRP University, Jaipur, IN

Abstract

The incidence of Breast Cancer is increasing, particularly in previously low incidence area such as Asian developing country like India. In the Present article Authors tried to review the Breast cancer statistics with the help of Graphical data. The comprehensive study also review with special account on causes, cancer types, different stages sign and symptoms, methods of detecting with their treatments as Radio therapy, Chemotherapy, Surgery and also have shown the various food and nutraceuticals which can be used as a preventive food for cancer.

Keywords

Breast Cancer, Statistics, Causes, Stages, Diagnosis, Treatment.

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K. G. Malviya ¹, U. D. Shivhare ², Preeti Srivastav ¹, S. C. Shivhare ¹

Affiliations
1 MJRP College of Heath Care and Allied Sciences, MJRP University, Jaipur, IN
2 Sharad Pawar College of Pharmacy, Nagpur, IN

Abstract

The present study was aimed at evaluating the chloroform extracts of whole part of Cyathocline lyrata cass for analgesic activity. The analgesic activity of chloroform extracts of whole part of Cyathocline lyrata cass was evaluated by Tail Flick Method and Hot Plate method. Chloroform extracts of whole part of Cyathocline lyrata cass produced significant analgesic activity when evaluated by Tail Flick Method/Hot Plate method. The interpretation of the results was done after subjecting the data obtained from various studies to statistical analysis which included one-way ANOVA followed by post-hoc with Dunnets t-test. The results suggest that the chloroform extracts of whole part of Cyathocline lyrata cass posses analgesic.

Keywords

Cyathocline lyrata cass, Analgesic, Tail Flick, Hot Plate.

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